Evidence map›Paper›PMID 41405578›Full record

ArticleThe Journal of experimental medicine2026

FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis.

Liling Xu, Maria Bottermann, Paula M Villavicencio, John Warner, Stephanie R Weldon, Zhenfei Xie, Andrew Filby, Xiaotie Liu, Ian G Ganley, Alison E Ringel and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liling XuBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0009-0001-4477-5380
Maria BottermannBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0000-0002-8178-100X
Paula M VillavicencioBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0009-0008-2321-9669
John WarnerBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0009-0001-1043-1643
Stephanie R WeldonBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0000-0001-5384-9946
Zhenfei XieBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0009-0006-9341-4721
Andrew FilbyInstitute of Cellular Medicine, Newcastle University , Newcastle upon Tyne, UK.ORCID 0000-0001-9078-4360
Xiaotie LiuBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0009-0001-5759-3498
Ian G GanleyMedical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee , Dundee, UK.ORCID 0000-0003-1481-9407
Alison E RingelRingel Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0000-0002-6451-9376
Usha NairBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0000-0002-1927-6889
Facundo D BatistaBatista Lab, The Ragon Institute of Mass General Brigham, MIT, and Harvard , Cambridge, MA, USA.ORCID 0000-0002-1130-9463

Funding

The Role of Canonical and Non-canonical Autophagy in B Cell ImmunityR01AI135052 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BATISTA, FACUNDO DAMIAN · 2018 to 2022
$2.3M
NIAID NIH HHS R01 AI135052NIH HHS R01AI135052The Ragon Institute of Mass General Brigham, MIT, and Harvard
6 · The paper itself

Abstract

Little is known about the role of autophagy in the human humoral immune system. Here, we found that in B cells, genetic ablation of FIP200, a mammalian metabolic sensor that regulates autophagy in response to a range of stimuli, led to diminished humoral immune responses in mice. FIP200-deficient B cells displayed decreased differentiation into plasma cells, as well as mitochondrial dysfunction, alterations in heme biosynthesis, and significant cell death. Notably, the addition of heme was sufficient to rescue plasma cell differentiation of FIP200-deficient B cells. Thus, FIP200 determines B cell fates by controlling mitophagy and metabolic reprogramming.

Indexed as

Autophagy-Related ProteinsB-LymphocytesCell DifferentiationHemeHomeostasisMitochondriaPlasma CellsAnimalsAutophagyHumansMiceMice, Inbred C57BLMice, KnockoutMitophagyAutophagy-Related ProteinsHeme

Identifiers

PMID41405578
PMCPMC12710606

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.