ArticleBrain and behavior2025
Association Between Self-Reported Sleep Quality and Conversion From Mild Cognitive Impairment to Dementia: A Retrospective Cohort Study Using the English Longitudinal Study of Ageing.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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3 authors.
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Abstract
purposePoor sleep quality is common in people diagnosed with mild cognitive impairment (MCI) and dementia and may be associated with conversion to dementia.
methodThis retrospective cohort study investigated the association of self-reported sleep quality and duration with dementia incidence in a cohort of people aged ≥ 50 with MCI from the English Longitudinal Study of Ageing (ELSA) panel study. We identified the MCI cohort using three waves (2008/2009, 2012/2013, 2016/2017) based on absence of diagnosed dementia, self-reported memory problems, preserved ability for daily activities, and reduced cognitive function in neuropsychological assessments. Exposures were self-reported poor sleep quality and sleep duration in the month before the baseline interview. The outcome was self-reported physician-diagnosed dementia from later waves. We modeled associations with Cox proportional hazards regression adjusted for multiple confounders. FINDING: Among 1885 patients with MCI at baseline, 24.7% reported poor sleep quality, 17.6% reported average sleep duration per night to be < 6 h, 74.6% reported average sleep duration per night to be 6-< 9 h, and 7.5% reported average sleep duration per night to be ≥ 9 h. Note that 176 (9.3%) developed dementia during follow-up (median 5.8 years, interquartile range [IQR] 2.1-6.3). Age-adjusted hazard for all-cause dementia, compared to 6-< 9 h sleep duration, was increased with sleep duration ≥ 9 h (hazard ratio [HR] 2.57, 95% confidence interval [CI] 1.62-4.02) but not short sleep duration (HR 0.94, 95% CI 0.55-1.61); there was weak evidence of reduced risk in persons with poor sleep quality, compared to good sleep quality (HR 0.68, 95% CI 0.41-1.12).
conclusionWe found evidence for an association between long sleep duration and dementia risk in patients with MCI and limited evidence of an association between poor sleep quality and dementia.
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