ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
Subregional Amygdala Functional Connectivity at 3T: Comparison of High-Resolution 2D and 3D fMRI Acquisitions.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Subregional Amygdala Functional Connectivity at 3T: Comparison of High-Resolution 2D and 3D fMRI Acquisitions.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
4 authors.
Funding
Abstract
background and purposeAmygdala dysfunction is implicated in major depressive disorder. Despite wide acknowledgement of its heterogeneity, the amygdala is predominantly considered as a single entity and functional connectivity investigations have reported findings using standard or low spatial resolution functional MRI data. This study compared the capabilities of two high spatial resolution acquisition strategies, the gold standard 2D and a novel 3D, in identifying amygdala functional connectivity to other brain regions at a subregional level.
methodsResting state fMRI data were acquired at 3T in 10 healthy controls using both versions of a Gradient-Echo Echo Planar Imaging (GRE-EPI) sequence. Whole brain voxel-wise functional connectivity measures were calculated using the whole amygdala and six subregional seed regions-of-interest; left and right basolateral, centromedial and superficial.
resultsThe 3D data identified multiple stronger bilateral connections between both centromedial subregions, most notably to subcortical structures including brainstem and hippocampus, as well as intra-amygdala subregional connections. The 2D data displayed stronger connections to several cortical regions. Whole amygdala and subregional FC results differed.
conclusionsThis study identified underutilized capability in current fMRI acquisition techniques at 3T. 2D GRE-EPI sequences optimized for high spatial resolution with voxel volumes of 15.6 mm
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