Evidence map›Paper›PMID 41405451›Full record

Observational studyEuropean journal of neurology2025

Greek Registry for Amyotrophic Lateral Sclerosis (ALS-GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece.

Ioannis Liampas, Vasilios K Kimiskidis, Vasiliki Zouvelou, Dimitra Veltsista, Afroditi Moscholouri, Eleftherios Triantafyllou, Ariadni Daponte, Sofia Xirou, Angeliki-Erato Sterpi, Stavroula Salakou and 20 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Ioannis LiampasDepartment of Neurology, University Hospital of Patras, University of Patras, Patras, Greece.
Vasilios K KimiskidisFirst Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0002-3335-3019
Vasiliki ZouvelouFirst Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Dimitra VeltsistaDepartment of Neurology, University Hospital of Patras, University of Patras, Patras, Greece.
Afroditi MoscholouriDepartment of Neurology, University Hospital of Patras, University of Patras, Patras, Greece.
Eleftherios TriantafyllouDepartment of Neurology, University Hospital of Patras, University of Patras, Patras, Greece.
Ariadni DaponteFirst Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Sofia XirouFirst Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Angeliki-Erato SterpiSecond Department of Neurology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Stavroula SalakouSecond Department of Neurology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Vasiliki PoulidouFirst Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0002-0147-3948
Marianthi ArnaoutoglouFirst Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Zisis TsourisDepartment of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Styliani RalliDepartment of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Efthimios DardiotisDepartment of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.ORCID 0000-0003-2957-641X
Sotirios PapagiannopoulosThird Department of Neurology, "G.Papanikolaou" Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Alexandros ZampetakisNeurology Department, PAGNI University Hospital of Heraklion, University of Crete, Crete, Greece.
Ιoannis ZaganasNeurology Department, PAGNI University Hospital of Heraklion, University of Crete, Crete, Greece.ORCID 0000-0002-0774-5772
Panayiotis MitsiasNeurology Department, PAGNI University Hospital of Heraklion, University of Crete, Crete, Greece.
Alexandros GiannakisDepartment of Neurology, University Hospital of Ioannina, Ioannina, Greece.
Spyridon KonitsiotisDepartment of Neurology, University Hospital of Ioannina, Ioannina, Greece.ORCID 0000-0002-5217-1317
Fotios KefalasEvaggelismos General Hospital, Athens, Greece.
Eleni AlexiouEvaggelismos General Hospital, Athens, Greece.
Panagiotis StoiloudisSecond Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dimitrios ParissisSecond Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Stratis KiamelidisNeurology Department, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Aikaterini TerzoudiNeurology Department, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Georgios TsivgoulisSecond Department of Neurology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.ORCID 0000-0002-0640-3797
Michail RentzosFirst Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Elisabeth ChroniDepartment of Neurology, University Hospital of Patras, University of Patras, Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiological studies on amyotrophic lateral sclerosis (ALS) in Greece are scarce and outdated.

methodsWe performed an observational cohort study in 11 specialized centres across Greece. Adult individuals with ALS diagnosed based on the Gold Coast criteria were recruited. Data were collected on socio-demographics, somatometrics, comorbidities, early life exposures, disease-related parameters, riluzole intake, motor and non-motor symptoms, as well as functional progression. Follow-up evaluations were scheduled on approximately 6-9-12-18-24 months. Our aim was to identify shortcomings in the monitoring of patients with ALS in specialized centers, delineate the course of the disease, and capture factors related to the earlier occurrence of ALS and potential diagnostic delays.

resultsA total of 229 ALS patients were included in the present registry. The average age of diagnosis was 63.7 years, with an average 12.8-month interval between symptom onset and diagnosis. The presence of bulbar symptoms at onset was associated with shorter diagnostic delays. Systematic physical exercise was strongly linked to the earlier onset of symptoms. Disease progression was slower during the prediagnostic stage, more precipitous over the first year following diagnosis, and milder thereafter (~1-point monthly decline in ALSFRS-R on average, post-diagnosis). The majority of associated motor and non-motor symptoms accumulated over time. The overwhelming majority of patients were prescribed the liquid form of riluzole, which exhibited an excellent tolerability profile. Greek islands are probably the most underprivileged in terms of specialized monitoring of ALS cases.

conclusionsThe present observational cohort study mapped key aspects and shortcomings of ALS management in Greece.

Indexed as

Amyotrophic Lateral SclerosisRegistriesAdultAgedCohort StudiesDisease ProgressionFemaleGreeceHumansMaleMiddle AgedRiluzoleRiluzoleALSFRS‐Rdiagnostic delayepidemiologyphysical exerciseriluzole

Identifiers

PMID41405451
PMCPMC12710438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.