Evidence map›Paper›PMID 41405443›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Acceptable standards for clinic-based digital cognitive assessments: Recommendations from the Global CEO Initiative on Alzheimer's Disease.

Louisa I Thompson, Barak Gaster, Dustin B Hammers, Sol Fittipaldi, A M Barrett, Katherine A Partrick, Emily Scholler, Benjamin Tiede, Christopher R Butler, CEOi Digital Cognitive Assessment Workgroup

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Louisa I ThompsonDepartment of Psychiatry & Human Behavior, Department of Family Medicine, Brown University, Alpert Medical School, Providence, Rhode Island, USA.
Barak GasterDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Dustin B HammersDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sol FittipaldiLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
A M BarrettDepartment of Neurology, Neurology Service, UMass Chan Medical School, UMass Memorial Health, Veteran Affairs, Central Western Massachusetts Health Care System, Worcester, Massachusetts, USA.
Katherine A PartrickThe Global CEO Initiative on Alzheimer's Disease, Wayne, Pennsylvania, USA.
Emily SchollerThe Global CEO Initiative on Alzheimer's Disease, Wayne, Pennsylvania, USA.
Benjamin TiedeThe Global CEO Initiative on Alzheimer's Disease, Wayne, Pennsylvania, USA.
Christopher R ButlerThe George Institute for Global Health, Imperial College London, London, UK.
CEOi Digital Cognitive Assessment Workgroup

Funding

Accelerating digital cognitive screening for Alzheimer's disease in the Primary Care SettingK23AG080159 · NIA · BROWN UNIVERSITY · PI Louisa Thompson · 2023 to 2026
$721k
Medication self-administration (MSA) and awareness of MSA: life-relevant markers of cognitive impairmentR56AG091682 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BARRETT, A. M., LIN, HONGHUANG · 2025 to 2025
$643k
BiogenEisaiEli LillyGBHI, Alzheimer's Association, and Alzheimer's Society GBHI ALZ UK‐24‐1068607National Institutes of Health (NIA/NIH K23AG080159NIA NIH HHS R56 AG091682
6 · The paper itself

Abstract

The rising prevalence of mild cognitive impairment (MCI) and dementia, combined with persistent underdiagnosis, is driving an increased need for scalable cognitive assessment tools. Digital cognitive assessments (DCAs) offer a promising solution by addressing longstanding barriers to routine cognitive testing and diagnosis. However, variations in performance and intended use have created confusion about their clinical applications and utility. The Global CEO Initiative on Alzheimer's Disease convened a DCA Workgroup to define the preferred characteristics of DCAs to meet the needs of patients, health care providers, and regulators for three clinical contexts: (1) initial detection of cognitive impairment, (2) diagnostic support for MCI and dementia, and (3) characterization of cognitive profiles to support identifying etiology. In the near term, ensuring that DCAs meet or exceed the performance of non-digital tools is a priority. DCAs must be validated in the intended use population with well-characterized study samples and inclusive designs.

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeuropsychological TestsHumansAlzheimer's diseaseAlzheimer's disease and related dementiasclinical practicecognitive assessmentcognitive impairmentcognitive testingdiagnosisdigital cognitive assessmentearly detectionmild cognitive impairmentprimary carespecialty care

Identifiers

PMID41405443
PMCPMC12710439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.