Evidence map›Paper›PMID 41405370›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Beyond Catalytic Therapy: Copper-Paeonol Nanozymes Disrupt Fascin-Mediated Actin Bundling to Suppress Tumor Growth and Metastasis.

Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peiying ZhangSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Huajun LiSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Yisen WangSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Jie XiangSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Lei FanSchool of Chemistry and Materials, Yangzhou University, Yangzhou, Jiangsu, 225002, China.
Shengzhe ZhangSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Lizeng GaoCAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.ORCID https://orcid.org/0000-0003-0265-4027
Hua DaiSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Juqun XiSchool of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.

Funding

National Natural Science Foundation of China 22472146Natural Science Foundation of Jiangsu Province BK20231329
6 · The paper itself

Abstract

Fascin, an actin-bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and invadopodia formation, establishing it as a pivotal therapeutic target. Herein, copper-paeonol nanozymes (CuPaeNs) is engineered through metal-phenolic complexation, mimicking natural enzyme metal-coordination microenvironments to confer peroxidase-like activity. This enzymatic capability drives the conversion of tumor-associated H

Indexed as

ActinsCarrier ProteinsCopperMicrofilament ProteinsAnimalsCell Line, TumorCell ProliferationHumansMiceNeoplasm MetastasisOxidative StressReactive Oxygen SpeciesActinsCarrier ProteinsCopperfascinMicrofilament ProteinsReactive Oxygen Speciesactin‐bundling activitycatalytic therapyfascinmetal‐phenolic nanozymestumor metastasis

Identifiers

PMID41405370
PMCPMC13042531

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.