Evidence map›Paper›PMID 41405234›Full record

GuidelineHepatology (Baltimore, Md.)2026

AASLD AST Practice Guideline on adult liver transplantation: Candidate evaluation.

Lorna Dove, Ryan M Chadha, Jennifer C Lai, Andrea DiMartini, AnnMarie Liapakis, Neehar D Parikh, Roberto Firpi-Morell, Lanla Conteh, Michael Fallon, James Trotter and 3 more

Abstract readPractice Guideline
In one paragraph

Guideline in Hepatology (Baltimore, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorna DoveColumbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0001-7083-8309
Ryan M ChadhaMayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0002-7463-6912
Jennifer C LaiUniversity of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-2092-6380
Andrea DiMartiniUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.ORCID 0000-0003-4883-121
AnnMarie LiapakisNYU Langone Transplant Institute, New York, New York, USA.ORCID 0000-0003-4484-6190
Neehar D ParikhUniversity of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-5874-9933
Roberto Firpi-MorellUniversity of Florida, Gainesville, Florida, USA.ORCID 0009-0005-3442-1596
Lanla ContehUniversity of Kentucky College of Medicine, Lexington, Kentucky, USA.ORCID 0000-0002-4372-993
Michael FallonUniversity of Arizona College of Medicine, Phoenix, Arizona, USA.ORCID 0000-0003-4087-803
James TrotterIntermountain Medical Center, Murray, Utah, USA.ORCID 0000-0001-8291-7784
Daniela P LadnerNorthwestern Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-5526-8272
Gonzalo SapisochinUniversity Hospital Vall d' Hebron, Barcelona, Spain.ORCID 0000-0001-9527-8723
Michael R LuceyUniversity of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0002-0380-7980

Funding

The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular CarcinomaK24AG080021 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2023 to 2026
$755k
NIA NIH HHS K24 AG080021
6 · The paper itself

Abstract

BACKGROUND AND

aimsLiver transplant is a specialized treatment for a spectrum of indications that use a scarce resource. Transplant is guided by principles of justice, equity, and benefit, with a constant conflict between competing interests. Organs are a national resource with a goal of equitable distribution across sites. An AASLD guideline for the evaluation and selection of appropriate candidates for transplant has been available since 2005.

methodsA multidisciplinary writing group of liver transplant experts and a librarian convened over 24 months. The writing group reviewed the literature, generated guideline recommendations, and rated the level of evidence for each recommendation based on the Oxford Center for Evidence-Based Medicine. The group categorized the strength of recommendations based on the level of evidence, risk-benefit ratio, and patient preferences.

conclusionsLiver transplant is a lifesaving procedure that should be offered to selected patients with clear indications and a reasonable prospect of benefit. The evaluation is designed to identify those in need, to outline hurdles to a successful outcome, and to develop an effective transplant plan. The goal of this document is to provide a template for this process.

Indexed as

Liver TransplantationPatient SelectionAdultEvidence-Based MedicineHumansSocieties, Medicalacute liver failurecardiopulmonary evaluationcirrhosiscontraindicationsevaluationfrailtyhepatocellular carcinomaliver transplantliving donor liver transplantnutritionportal hypertensionpsychosocial evaluation

Identifiers

PMID41405234
PMCPMC13070310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.