Evidence map›Paper›PMID 41405205›Full record

ArticlemSystems2026

Updated Erdman reveals tandem repeat copy number is phase-variable and impacts

Samuel J Modlin, Nachiket Thosar, Paulina M Mejía-Ponce, Raegan L Lunceford, Gaelle Guiewi Makafe, Brian Weinrick, Faramarz Valafar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Heteroresistance inFrontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samuel J Modlin *Laboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.ORCID 0000-0002-7674-305X
Nachiket Thosar *Laboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.ORCID 0000-0002-5069-0236
Paulina M Mejía-PonceLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.
Raegan L LuncefordLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.
Gaelle Guiewi MakafeTrudeau Institute, Saranac Lake, New York, USA.
Brian WeinrickTrudeau Institute, Saranac Lake, New York, USA.ORCID 0000-0003-0880-4487
Faramarz ValafarLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, School of Public Health, San Diego State University, San Diego, California, USA.ORCID 0000-0002-3648-9384

Funding

Evolutionary and Functional Significance of Novel Mutations in MDR-XDR TBR01AI105185 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2013 to 2021
$5.3M
Undetected Drug resistance and Tolerance in lesions of recurrent TBR01AI163202 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2022 to 2025
$2.8M
National Institute of Allergy and Infectious Diseases R01AI105185National Institute of Allergy and Infectious Diseases R01AI163202NIAID NIH HHS R01 AI105185NIAID NIH HHS R01 AI163202
6 · The paper itself

Abstract

High-quality reference genomes are essential for comparative genomics and accurate genotype-phenotype mapping. Here, we corrected the IMPORTANCE:

Indexed as

Adaptation, PhysiologicalDNA Copy Number VariationsEvolution, MolecularMycobacterium tuberculosisTandem Repeat SequencesGenome, BacterialHumanscopy numberevolutionMycobacterium tuberculosisphase variationstress adaptationtandem repeat

Identifiers

PMID41405205
PMCPMC12817950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.