ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2025
Arginine Metabolism in Decidual Macrophages During Pregnancy.
Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Immunopathology of Preeclampsia.Biomedicines · 2026Review
- Arginine Metabolism in Decidual Macrophages During Pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundMaternal immune tolerance to the semi-allogeneic fetus is essential for successful pregnancy, while immune defense against pathogens must be preserved. Decidual macrophages (DMs) are critical regulators at the maternal-fetal interface, involved in trophoblast invasion, vascular remodeling, and immune modulation.
methodsThis review integrates findings from human studies, animal models, and in vitro experiments to explore how arginine metabolism regulates macrophage polarization and pregnancy outcomes.
resultsArginine metabolism influences DM function via two major pathways: iNOS promotes M1 polarization and pro-inflammatory activity, while Arg-1 supports M2 polarization, tissue remodeling, and immune tolerance. Dysregulation of this balance is associated with pregnancy complications such as pre-eclampsia and fetal growth restriction. Pathogens like Helicobacter pylori and Mycobacterium tuberculosis exploit Arg-1 activity to evade host immunity. Clinical studies also suggest that L-arginine supplementation can improve placental function and fetal growth.
conclusionArginine metabolism is a key modulator of macrophage polarization and immune balance in pregnancy. Targeting this pathway may offer novel therapeutic strategies to improve maternal and fetal outcomes.
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Registered trials
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