ReviewNucleic acids research2025
Eukaryotic translation initiation factor 4F: functional properties and physiological role.
Review in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.Nucleic acids research · 2026Article
- Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.bioRxiv : the preprint server for biology · 2026Article
- Review
- Remodeling of mRNA by eIF4F in human translation initiation.bioRxiv : the preprint server for biology · 2026Article
- Proteolytic dissection of eIF4G reveals the closed-loop mRNP as an architecture for translation repression.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Successful translation requires multiple protein factors with diverse specific activities. Initiation of translation is regarded as the most tightly regulated step of this process, controlled by numerous factors. Among these is the eukaryotic initiation factor 4F (eIF4F), a protein complex composed of three subunits: the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffolding protein eIF4G. While significant progress has been made in elucidating the structure and functions of eIF4F, several key questions remain unresolved concerning its mechanistic contributions to translational control. In this review, we discuss the roles of eIF4F in translation and its regulatory functions under diverse cellular conditions. Dysregulation of eIF4F is frequently implicated in a wide range of physiological abnormalities, confirming its critical role in the cell. We also review recent studies that position eIF4F as a global cellular regulator and expand our understanding of its role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.