Evidence map›Paper›PMID 41404756›Full record

ArticleJournal of the American Heart Association2026

Association of Nontraditional Lipid Parameters With Long-Term Prognosis of Acute Ischemic Stroke: A Principal Components Analysis.

Hai Lin, Wei Xie, Suwen Huang, Jialing Lou, Rui Zhang, Bohuai Yu, Guoliang Zhou, Yanyi Pan, Taili Wu, Xiaoyan Huang and 6 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hai LinDepartment of Endocrinology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Wei XieDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Suwen HuangDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Jialing LouDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Rui ZhangDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Bohuai YuDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.ORCID 0009-0009-5234-348X
Guoliang ZhouDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Yanyi PanDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Taili WuDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Xiaoyan HuangDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Fangyan ChenDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Changhao ZhangDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Yuxin ZhuDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Yiyun WengDepartment of Neurology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.ORCID 0000-0002-1407-4276
Dehao YangDepartment of Neurology The Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China.ORCID 0000-0002-4129-9761
Guangyong ChenDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China.ORCID 0000-0003-1818-6280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLipids can adversely affect the prognosis of acute ischemic stroke (AIS). Unlike traditional lipids, nontraditional parameters can offer more extensive insights, but their significance in AIS remains unexplored. This study aimed to evaluate the association between 11 lipid parameters and AIS comprehensively.

methodsWe leveraged data from 1858 participants with AIS without intravenous thrombolysis to examine the relationship between nontraditional lipid parameters and 1-year prognostic outcomes. The principal component analysis was used to comprehensively assess the prognostic value of nontraditional lipid parameters.

resultsFour nontraditional lipid parameters, plasma atherosclerotic index, atherosclerosis coefficient, Castelli's index-II, and lipoprotein combine index were selected by random forest. Among them, Castelli's index-II was the strongest and most comprehensive predictor of the prognosis of patients with AIS and was associated with 1-year all-cause mortality (hazard ratio [HR],0.571 [95% CI, 0.342-0.954],

conclusionsNontraditional lipid parameters, especially Castelli's index-II may serve as a new AIS prognostic outcomes indicator. Constructed composite principal component analysis score for lipids was associated with all-cause mortality at 1 year.

Indexed as

Brain IschemiaIschemic StrokeLipidsPrincipal Component AnalysisAgedBiomarkersFemaleHumansMaleMiddle AgedPrognosisRisk AssessmentRisk FactorsTime FactorsBiomarkersLipidsacute ischemic strokenontraditional lipid parametersprincipal components analysis

Identifiers

PMID41404756
PMCPMC12909042

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