ArticleJournal of the American Heart Association2026
Differential Left and Right Carotid Artery Blood Flow and Altered Hippocampal Mitochondrial Function After Transverse Aortic Constriction in Aging Rats.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe hippocampus is a key brain structure that has been implicated in vascular dementia cause and is highly sensitive to changes in cerebral blood flow. Brain hypoperfusion in cardiovascular disease may facilitate neurodegeneration in the hippocampus by limiting substrate transport and metabolism. Although most animal studies have relied on artery occlusion to lower brain blood flow, brain hypoperfusion can also stem from mechanical damage resulting from high blood flow velocity and pulsatility. This study assessed, within the same rodent, whether high and low cerebral blood flow differentially affected hippocampal glucose transport protein expression, mitochondrial fuel oxidation, and expression of mitochondrial quality control proteins.
methodsFour-week-old male and female Sprague-Dawley rats underwent transverse aortic constriction (n=13) or control (n=18) surgeries. Bilateral carotid artery diameter and blood flow were measured 20, 30, and 40 weeks postsurgery. Right and left hippocampal mitochondrial respiration and expression of glucose transporters and mitochondrial quality control proteins were measured 40 weeks postsurgery.
resultsRight carotid blood flow velocity and pulsatility were highest in the right and lowest in the left carotid of transverse aortic constriction animals (
conclusionsAlthough both limited and pulsatile blood flow alter mitochondrial fusion markers, only pulsatile flow impairs mitochondrial respiration, suggesting turbulent hemodynamics may drive metabolic dysfunction in vascular dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.