Evidence map›Paper›PMID 41404733›Full record

Trial reportJournal of the American Heart Association2026

Artificial Intelligence-Based Automated Echocardiographic Analysis and the Workflow of Sonographers: A Randomized Crossover Trial (AI-Echo RCT).

Akira Sakamoto, Nobuyuki Kagiyama, Eiichiro Sato, Yutaka Nakamura, Azusa Murata, Tomohiro Kaneko, Sakiko Miyazaki, Yuko Ashikawa, Kenichi Sugihara, Tohru Minamino

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Automated Phenotyping of Mitral Stenosis Using Deep Learning.medRxiv : the preprint server for health sciences · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Comprehensive aortic stenosis characterization using multi-view deep learning.medRxiv : the preprint server for health sciences · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akira SakamotoDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0009-0004-1652-9328
Nobuyuki KagiyamaDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0000-0002-2305-0049
Eiichiro SatoDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0009-0002-2575-2957
Yutaka NakamuraDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
Azusa MurataDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0000-0001-6597-2730
Tomohiro KanekoDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0000-0001-9355-2418
Sakiko MiyazakiDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.
Yuko AshikawaM3AI Inc. Tokyo Japan.
Kenichi SugiharaM3AI Inc. Tokyo Japan.
Tohru MinaminoDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine Tokyo Japan.ORCID 0000-0003-1627-6151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis trial evaluated whether an artificial intelligence (AI)-based automatic analysis for echocardiography could improve sonographer workflow in real-world clinical practice.

methodsIn a single-center crossover trial, 4 sonographers were randomly assigned to use AI assistance (AI days) or manual workflow (non-AI days) on a daily basis. The AI tool automatically measured echocardiographic parameters, allowing sonographers to focus on verifying AI-generated values. Expert echocardiologists finalized all reports. The primary end point was examination efficiency, measured by examination time per patient and number of examinations per day. Secondary end points included sonographer fatigue, the number of analyzed echocardiographic parameters, and image quality.

resultsA total of 585 patients were scanned over 38 study days (AI days, 317; non-AI days, 268) between January 30 and March 26, 2024. Baseline characteristics were comparable between groups. AI assistance significantly reduced examination time (13.0±3.5 minutes versus 14.3±4.2 minutes,

conclusionsThis real-world randomized trial demonstrated that AI-based echocardiographic analysis enhances workflow efficiency, reduces sonographer fatigue, and improves image quality without compromising diagnostic integrity. AI integration holds promise for optimizing high-volume echocardiography workflows. REGISTRATION: URL: https://center6.umin.ac.jp. Unique identifier: UMIN000053259.

Indexed as

Artificial IntelligenceEchocardiographyImage Interpretation, Computer-AssistedWorkflowAgedCross-Over StudiesFemaleHumansMaleMiddle Agedartificial intelligenceautomated analysisechocardiographyrandomized trialwork burden

Identifiers

PMID41404733
PMCPMC12909003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.