Evidence map›Paper›PMID 41404704›Full record

ArticleNucleic acids research2026

VirJenDB: a FAIR (meta)data and bioinformatics platform for all viruses.

Shahram Saghaei, Malte Siemers, Kilian L Ossetek, Stephan Richter, Robert A Edwards, Simon Roux, Andrzej Zielezinski, Bas E Dutilh, Manja Marz, Noriko A Cassman

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shahram SaghaeiRNA Bioinformatics and High-Throughput Analysis, Faculty of Computer Science and Mathematics, Friedrich Schiller University Jena, Jena 07743, Germany.ORCID 0009-0005-5554-275X
Malte SiemersInstitute of Biodiversity, Ecology, and Evolution, Faculty of Biological Sciences, Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena 07745, Germany.ORCID 0000-0001-8458-1938
Kilian L OssetekRNA Bioinformatics and High-Throughput Analysis, Faculty of Computer Science and Mathematics, Friedrich Schiller University Jena, Jena 07743, Germany.ORCID 0009-0007-0313-2593
Stephan RichterRNA Bioinformatics and High-Throughput Analysis, Faculty of Computer Science and Mathematics, Friedrich Schiller University Jena, Jena 07743, Germany.ORCID 0009-0007-2526-5012
Robert A EdwardsFlinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide 5001, Australia.ORCID 0000-0001-8383-8949
Simon RouxU.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-5831-5895
Andrzej ZielezinskiInstitute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan 61-712, Poland.ORCID 0000-0002-8096-3776
Bas E DutilhInstitute of Biodiversity, Ecology, and Evolution, Faculty of Biological Sciences, Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena 07745, Germany.ORCID 0000-0003-2329-7890
Manja MarzRNA Bioinformatics and High-Throughput Analysis, Faculty of Computer Science and Mathematics, Friedrich Schiller University Jena, Jena 07743, Germany.ORCID 0000-0003-4783-8823
Noriko A CassmanRNA Bioinformatics and High-Throughput Analysis, Faculty of Computer Science and Mathematics, Friedrich Schiller University Jena, Jena 07743, Germany.ORCID 0000-0003-1655-0931

Funding

Alexander von Humboldt FoundationAustralian Research Council DP220102915Australian Research Council DP250103825Australian Research Council FL250100019Deutsche Forschungemeinschaft 460129525European Research Council 865694Federal Ministry of Education and ResearchFriedrich-Schiller-Universität JenaGerman Federal Ministry of Health ZMII2-2524FSB62CGermany's Excellence Strategy EXC 2051 390713860Horizon Europe programme 101046203NFDI4MicrobiotaPHIU.S. Department of Energy DE-AC02-05CH11231U.S. Department of Energy Joint Genome Institute
6 · The paper itself

Abstract

High-throughput sequencing has generated an unprecedented volume of data. However, researcher-submitted data in repositories requires extensive curation and quality control for reuse. These tasks are hindered by the multiplicity of repositories, the sheer volume of the data, and the complexity of virus (meta)data curation. To address these challenges, VirJenDB offers a user-friendly platform to facilitate versioned, community-driven curation, and ontology development. Virus sequences were ingested from 16 sources, including ~200 fields of metadata or standards, covering taxonomy, sample, and host information. Up to 85 metadata fields have undergone at least one round of curation, and are linked to 15.4 million virus sequences, with 88 % from those infecting eukaryotes and the remaining infecting prokaryotes. Subsets were created, including a novel collection of 0.91 million viral operational taxonomic unit (vOTU) sequences across all viruses, while keeping the original sequences from each vOTU to facilitate downstream analyses, e.g. sequence variation. The VirJenDB web portal (https://www.virjendb.org) provides HTTPS and Application Programming Interface (API) access to the sequence datasets and metadata, offering a search engine, filtering, download, visualizations, and documentation. VirJenDB aims to connect the phage and eukaryotic virus research communities by supporting webtool integration, meta-analyses, and metadata schema extensions.

Indexed as

Computational BiologyDatabases, GeneticSoftwareVirusesData CurationGenome, ViralHigh-Throughput Nucleotide SequencingInternetMetadata

Identifiers

PMID41404704
PMCPMC12807664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.