Evidence map›Paper›PMID 41404590›Full record

ArticleFrontiers in medicine2025

Adult onset multisystem Langerhans cell histiocytosis initially presenting with arginine vasopressin deficiency: a case report.

Dan Zeng, Mingyu Hao, Liming Zhou, Yuli Wang, Junying Liu, Shujuan Chen, Litao Zheng, Yeyu Yang, Haiyan Li

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan Zeng *Department of Endocrinology, Shenzhen Scond People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Clinical Research Center for Metabolic Diseases, Shenzhen, China.
Mingyu Hao *Department of Endocrinology, Shenzhen Scond People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Clinical Research Center for Metabolic Diseases, Shenzhen, China.
Liming ZhouDepartment of Endocrinology, Shenzhen Scond People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Clinical Research Center for Metabolic Diseases, Shenzhen, China.
Yuli WangDepartment of Radiology, Shenzhen Second People's Hospital, Health Science Center of Shenzhen University, Shenzhen, China.
Junying LiuDepartment of Endocrinology, Shenzhen Scond People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Clinical Research Center for Metabolic Diseases, Shenzhen, China.
Shujuan ChenDepartment of Endocrinology, Shenzhen Scond People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Clinical Research Center for Metabolic Diseases, Shenzhen, China.
Litao ZhengDepartment of Endocrinology, Shenzhen Scond People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Clinical Research Center for Metabolic Diseases, Shenzhen, China.
Yeyu YangGuangzhou University of Chinese Medicine-Shenzhen Hospital Zhulin Community Health Service Station, Shenzhen, China.
Haiyan LiDepartment of Endocrinology, Shenzhen Scond People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen Clinical Research Center for Metabolic Diseases, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Langerhans cell histiocytosis (LCH) is a rare hematopoietic disorder with diverse clinical presentations and sequential or concurrent multi-organ involvement. The adult onset is particularly uncommon and challenging to diagnose early. Case presentation: A 36-year-old female patient initially presented with polydipsia, polyuria, and dry mouth, gradually developing bone pain, facial erythema, and lymph node enlargement. Cranial MRI showed pituitary stalk thickening with the absence of a posterior pituitary signal. Iliac bone biopsy with immunohistochemistry demonstrated S-100(+), CD1a(+), and CD68(+) expression. After Systemic Chemotherapy and DDAVP administration, follow-up showed improvement of polyuria, polydipsia, and polyphagia, remission of osseous pain, regression of cutaneous manifestations, normalized pituitary stalk morphology, and reduced lesion metabolic activity. Conclusion: This report documents a complex and rare case to improve early diagnosis, reduce misdiagnosis, and prevent poor outcomes from delayed treatment.

Indexed as

arginine vasopressin deficiencycase reportLangerhans cell histiocytosismultisystemic involvementpituitary stalk thickening

Identifiers

PMID41404590
PMCPMC12702692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.