ArticleFrontiers in medicine2025
Association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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3 authors.
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Abstract
Background: Age-related eye diseases are the main causes of progressive and irreversible vision loss in aging populations worldwide. Carotenoids, as a group of common natural antioxidants, can suppress free radicals produced by complex physiological reactions, thereby protecting the eyes from the effects of oxidative stress, cell apoptosis, and mitochondrial dysfunction. The present study aims to explore the association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults in the United States. Methods: This study involved 1,478 participants aged ≥50 years from the 2005-2006 cycles of the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of prevalence of cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) in relation to serum carotenoid concentrations. Results: Compared to participants in the first quartile, those in highest quartile of serum Conclusion: Our study demonstrated that higher serum concentrations of carotenoids were negatively associated with the risk of age-related eye diseases, particularly among middle-aged and older female participants.
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