Evidence map›Paper›PMID 41404530›Full record

ArticleFood science & nutrition2025

Causal Relationship Between Circulating Omega-3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study.

Yaodan Zhang, Lingxue Gong, Xinmin Deng, Jingtao Liang, Xiaofeng Lv, Rui Lai, Meijun Liu

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaodan ZhangDepartment of Neurology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China.ORCID https://orcid.org/0009-0006-7807-9128
Lingxue GongClinical Medical College Guizhou Medical University Guiyang China.
Xinmin DengDepartment of Neurology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China.
Jingtao LiangDepartment of Neurology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China.
Xiaofeng LvSchool of Acupuncture and Moxibustion Chengdu University of Traditional Chinese Medicine Chengdu China.
Rui LaiSchool of Acupuncture and Moxibustion Chengdu University of Traditional Chinese Medicine Chengdu China.
Meijun LiuDepartment of Neurology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral small vessel disease (CSVD) plays an important role in the onset of stroke and cognitive dysfunction. Its primary imaging manifestations encompass lacunar stroke (LS), white matter hyperintensity (WMH), white matter perivascular space (WMPVS), and cerebral microbleed (CMB). While omega-3 fatty acid (FA) has shown potential protective effects against vascular diseases, their causal role in CSVD remains unclear. This study aims to investigate the causal relationship between circulating Omega-3 FA levels and various CSVD phenotypes using Mendelian randomization (MR). Data on circulating omega-3 FA levels were derived from a large genome-wide association study (GWAS) summary dataset comprising 115,060 individuals. Data on CSVD phenotypes were obtained from several large GWAS datasets, including those on LS (6030 cases, 248,929 controls), WMH (

Indexed as

causal relationshipcerebral microbleedcerebral small vessel diseaseomega‐3 fatty acid

Identifiers

PMID41404530
PMCPMC12703811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.