ArticleFrontiers in endocrinology2025
The intestinal microbiota of patients with type 2 diabetes is associated with the C-512T polymorphism of the FOXC2 gene.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Out"FOX"ing cancer: the implications of FOXC2 as a putative predictive biomarker for cancer immunotherapy.Frontiers in medicine · 2026Article
- The ethnicity and gut microbiota hypothesis: analyzing multifactorial interactions and their health implications.Frontiers in microbiology · 2026Review
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Authors and funding
6 authors.
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Abstract
Objective: To investigate the correlation between the C-512T polymorphism of the FOXC2 gene and intestinal microbiota in patients with T2DM. Methods: Peripheral blood and fecal specimens were collected from 170 patients with T2DM and tested for the C-512T polymorphism of the FOXC2 gene by DNA sequencing. Based on the genotype test results, 120 patients were finally included and divided into CC, CT, and TT groups (40 patients in each group). The structural composition and function of the intestinal microbiota were analyzed using 16S rRNA gene sequencing, and differences between groups of intestinal microbiota were assessed. Results: Alpha Diversity analysis suggested that there was no prominent difference in the abundance and diversity of intestinal microbiota among CC, CT, and TT groups. PCoA analysis in Beta diversity suggested that the composition of enteric flora might be different between CC and CT groups ( Conclusion: The C-512T polymorphism in the FOXC2 gene has been associated with the structural abundance and species composition of type 2 diabetic intestinal microbiota.
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