ReviewFrontiers in endocrinology2025
Application of circadian rhythm in osteoporosis prevention and treatment: from light, diet, and exercise to chronotherapy.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Rhythmic Metabolism in Osteosarcopenia: Emerging Evidence, a Chronometabolomic Framework for the Bone-Muscle Unit, and Research Priorities.Metabolites · 2026Review
- Circadian regulation of osteoclast lysosomal-resorption machinery: implications for osteoporosis therapy.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a prevalent systemic bone disorder characterized by reduced bone mass, deterioration of bone microstructure, and increased bone fragility, significantly compromising the quality of life, particularly among elderly and postmenopausal populations. The circadian clock serves as a critical physiological mechanism for maintaining homeostasis and regulating rhythmic biological processes, playing an essential role in bone metabolism regulation. Recent studies have revealed strong associations between circadian disruption and the development and progression of osteoporosis, providing novel perspectives for intervention strategies. This comprehensive review examines the role of the circadian clock in osteoporosis and explores the current applications and future prospects of circadian-based interventions, including light exposure, dietary modifications, physical activity, and chronotherapy, in osteoporosis management. The objective is to offer comprehensive and precise strategic insights for osteoporosis prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.