ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
The association between multiple long-term conditions and dementia: A UK cohort study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Laboratory-based turning performance during walking in people with mild cognitive impairment and dementia.Journal of Alzheimer's disease : JAD · 2026Article
- Multimorbidity research in dementia: it's time to shift to a person-centred approach.Frontiers in dementia · 2026Article
- The association between multiple long-term conditions and dementia: A UK cohort study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStudies examining the risk of dementia in people with multimorbidity are commonly conducted in research cohorts or outside the UK. Multimorbidity has historically been associated with aging, but recent research suggests that more than half of incidence cases occur in adults < 50.
methodsUsing UK primary care data, adjusted Cox regressions and competing risk of death models were used to determine risk of dementia in people with multimorbidity overall and by body system.
resultsPeople with multimorbidity had a greater risk of dementia that those without multimorbidity (hazard ratio [HR] = 4.01, 95% confidence interval [CI] 3.94-4.07). Among people with multimorbidity, the risk was highest for those when a neurological condition was included (HR = 2.19, 95% CI 2.15-2.23). DISCUSSION: Managing multimorbidity, particularly neurological conditions, is key and could delay or reduce the risk of dementia. Highlights: People with multimorbidity experienced a greater risk of dementia than those without.Neurological multimorbidity presented the highest risk of dementia.Risk of dementia increased progressively with younger-onset multimorbidity.Preventing or managing multimorbidity effectively could reduce or delay dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.