SynthesisFrontiers in neurology2025
The 200 most influential publications in migraine research: a bibliometric mapping of the intellectual landscape.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Migraine is a prevalent and highly disabling neurological disorder. A systematic evaluation of its foundational literature is essential for advancing management strategies. This study employed bibliometric methods to trace the historical trajectory of migraine research and identify principal developmental trends. Methods: The Web of Science and PubMed database was searched to identify the 200 most highly cited publications, filtered by date, language, and document type. Comprehensive analyses and visualizations were conducted using bibliometrix (R), VOSviewer, Scimago Graphica, CiteSpace, and Microsoft Excel. Results: The selected publications appeared in 45 journals across 45 countries, authored by 4,409 researchers from 1,592 institutions. Together, these works incorporated 860 keywords and cited 7,995 references. Neurology, Cephalalgia, and Headache were the leading journals, while Lipton RB and Goadsby PJ were the most influential authors. The United States led in publication volume, with Albert Einstein College of Medicine among the top institutions. Ten landmark papers were highlighted, and their contributions, along with those of the broader corpus, were systematically reviewed. Key research hotspots were also delineated. Conclusion: Current high-impact research emphasizes treatment, therapeutic targets, genetics, the trigeminovascular system, pain modulation, neuroimmunology, aura, and comorbidities. Recent studies confirm sustained interest in these areas, with increasing focus on the brain-gut axis. Future directions include deeper investigation of migraine pathophysiology, especially the calcitonin gene-related peptide system and episodic migraine subtypes. Rigorous methodologies and emerging technologies will enhance evidence-based evaluations of long-term safety and efficacy, while multidimensional assessments of pharmacological and non-pharmacological therapies are expected to expand.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.