ArticleFrontiers in neurology2025
HMOX1 mRNA combined with early imaging parameters for predicting the prognosis of hypertensive cerebral hemorrhage patients undergoing conservative treatment.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To address the limitations of current clinical tools in predicting the prognosis of hypertensive cerebral hemorrhage (HICH) patients undergoing conservative treatment, this study aimed to evaluate the predictive value of combining HMOX1 mRNA levels with early imaging parameters. Methods: This retrospective diagnostic accuracy study involved 208 HICH patients (mean age 50 ± 9.5 years, 149 men) treated from December 2022 to December 2024. Patients were divided into good prognosis (mRS score ≤ 2, Results: HMOX1 mRNA expression was higher in the poor prognosis group (1.36 ± 0.41 vs. 1.00 ± 0.22, Conclusion: The 'HMOX1 mRNA + imaging parameters' combined indicator and the nomogram model both significantly improve prognostic prediction accuracy in HICH patients undergoing conservative treatment, with the nomogram model showing the best efficiency.
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