ArticleFrontiers in pediatrics2025
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: The current standard treatment of Hirschsprung's disease (HD) involves complete resection of the aganglionic intestinal segment with routine rectal irrigation pre- and postoperatively. To date, our understanding of the underlying pathomechanisms is not sufficient to warrant modifying this therapeutic approach. Here, we utilized resected tissue specimens from children with HD to investigate spontaneous motility and cholinergic responses in circular muscle from both ganglionic and aganglionic colon Methods: Full-thickness intestinal samples (from both aganglionic and ganglionic segments) were obtained intraoperatively from children with HD undergoing pull-through surgery. After removing the mucosal tissue and longitudinal smooth muscle, we prepared specimens consisting of circular muscle layer and submucosal tissue. These deafferentiated specimens were mounted in the organ bath to record isometric forces during spontaneous motility or following cholinergic stimulation. Results: Regarding spontaneous motility, the basal tone was observed in all specimens, and phasic contractions were observed in 81% vs. 63% of ganglionic and aganglionic specimens, respectively. Both basal tone and phasic contractions were abolished in the presence of 40 mM EDTA indicating Ca Conclusions: We conclude that the circular muscle of aganglionic colonic segments retains the ability to establish a Ca
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