Hydrogel-Wrapped

Xuesong Wang, Zikun Xie, Riyue Wu, Pengcheng Gao, Liqin Chen, Junlin Zhong, Shuofei Yang, Lei Jin

Abstract read

In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Nanocarrier-Mediated Delivery Systems of Phytochemicals to Enhance and Accelerate Diabetic Wound Healing Processes.Drug design, development and therapy · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuesong WangDepartment of Stomatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210016, China.

Zikun XieDivision of Orthopaedic Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Riyue WuDepartment of Stomatology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

Pengcheng GaoSouthern Medical University, Guangzhou, Guangdong, 510515, China.

Liqin ChenSouthern Medical University, Guangzhou, Guangdong, 510515, China.

Junlin ZhongDepartment of Ultrasound, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Shuofei YangDepartment of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Road 160, Shanghai, 200127, China.

Lei JinDepartment of Stomatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fracture healing is a complex process often complicated by nonunion and delayed healing, with macrophage polarization being a key regulator of inflammation and tissue repair. Single-cell RNA sequencing (scRNA-seq) has identified genes highly expressed in M1 macrophages at fracture sites, which are closely linked to macrophage polarization. Plant-derived extracellular vesicles (EVs) have shown potential as anti-inflammatory agents but are limited by short duration of action and poor targeting. In this study, we used scRNA-seq to elucidate the mechanisms of M1 macrophage polarization during fracture healing and identified MMP12 as a target regulated by

Indexed as

Calendula officinalis L. -derived extracellular vesiclesFracture healingHydrogelMacrophage polarizationSingle-cell RNA sequencing

Identifiers

PMID41404424

DOI10.1016/j.mtbio.2025.102592

PMCPMC12704079

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.