Evidence map›Paper›PMID 41404423›Full record

ArticleMaterials today. Bio2025

EXO/hydrogel system for sequential regulation of endogenous hyaline cartilage regeneration.

Kang Wu, Rong Gong, Tianyu Gao, Yong Hu, Hongrui Wang, Weiye Zhang, Xiaoxu Wang, Yifan Wang, Ning Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kang WuDepartment of Foot and Ankle Surgery, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, China.
Rong GongKey Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Tianyu GaoDepartment of Foot and Ankle Surgery, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, China.
Yong HuDepartment of Foot and Ankle Surgery, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, China.
Hongrui WangDepartment of Foot and Ankle Surgery, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, China.
Weiye ZhangDepartment of Foot and Ankle Surgery, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, China.
Xiaoxu WangDepartment of Foot and Ankle Surgery, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, China.
Yifan WangSenior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.
Ning ZhangDepartment of Foot and Ankle Surgery, The Second Qilu Hospital of Shandong University, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Articular cartilage repair remains a clinically significant challenge due to its limited regenerative capacity and vulnerability to inflammation-induced damage and fibrocartilage formation. Current therapeutic strategies frequently fail to enhance intrinsic repair capacity or overcome the dual barriers of injury/inflammation-driven fibrosis and insufficient hyaline cartilage regeneration, often yielding suboptimal outcomes. Here, we developed an exosome-integrated hydrogel system for temporally programmed drug delivery. Kartogenin (KGN) and halofuginone (HF) were encapsulated into human umbilical cord MSC-derived exosomes (EXO

Indexed as

cGAS-STING pathwayHalofuginoneHyaline cartilage regenerationKartogeninTemporally programmed drug delivery

Identifiers

PMID41404423
PMCPMC12704077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.