Evidence map›Paper›PMID 41404293›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Local genetic correlation analysis of Alzheimer's disease and stroke implicates

Nicholas R Ray, Jiji Kurup, Ajneesh Kumar, Farid Rajabli, Liyong Wang, Wanying Xu, Fulai Jin, Elanur Yilmaz, Caghan Kizil, Luciana Bertholim-Nasciben and 44 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

54 authors.

Nicholas R RayColumbia University Irving Medical Center, New York, NY, USA.
Jiji KurupColumbia University Irving Medical Center, New York, NY, USA.
Ajneesh KumarColumbia University Irving Medical Center, New York, NY, USA.
Farid RajabliUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Liyong WangUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Wanying XuCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Fulai JinCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Elanur YilmazColumbia University Irving Medical Center, New York, NY, USA.
Caghan KizilColumbia University Irving Medical Center, New York, NY, USA.
Luciana Bertholim-NascibenUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Sofia MouraUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Aura M RamirezUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Olusegun BaiyewuCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Anthony J GriswoldUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Motunrayo CokerCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Kyle M ScottUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Kazeem AkinwandeCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Larry D AdamsUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Samuel DialaCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Patrice G WhiteheadUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Jacob L McCauleyUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Mayowa OgunronbiCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Kara L Hamilton-NelsonUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Albertino DamascenoFaculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Andrew F ZamanUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Susan H BlantonUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Albert AkpaluUniversity of Ghana Medical School, Accra, Ghana.
Michael L CuccaroUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Kolawole WahabDepartment of Medicine, University of Ilorin, Ilorin, Nigeria.
Katalina F McInerneyUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Karen NuytemansUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Reginald ObiakoAhmadu Bello University, Zaria, Kaduna, Nigeria.
Pedro R MenaUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Njideka OkubadejoCollege of Medicine, University of Lagos, Lagos, Nigeria.
Izri M MartinezUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Yared Z ZewdeCollege of Health Sciences of Addis Ababa University, Addis Ababa, Ethiopia.
Seid A GugssaCollege of Health Sciences of Addis Ababa University, Addis Ababa, Ethiopia.
Fred S SarfoKomfo Anokye Teaching Hospital, Kumasi, Ghana.
Raj KalariaInstitute for Ageing and Health, Newcastle University, Newcastle, United Kingdom.
David M NdeteiUniversity of Nairobi and Africa Institute of Mental and Brain Health, Kenya.
Scott M WilliamsCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Allison Caban-HoltWake Forest University School of Medicine, Winston-Salem, NC, USA.
ADGC
AfDC
Giuseppe TostoColumbia University Irving Medical Center, New York, NY, USA.
Jonathan L HainesCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Rufus O AkinyemiCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Adesola OgunniyiCollege of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Goldie S ByrdWake Forest University School of Medicine, Winston-Salem, NC, USA.
William S BushCase Western Reserve University School of Medicine, Cleveland, OH, USA.
Brian W KunkleUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Jeffery M VanceUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Margaret A Pericak-VanceUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Christiane ReitzColumbia University Irving Medical Center, New York, NY, USA.

Funding

Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)U19AG074865 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Brian William Kunkle · 2022 to 2026
$55.3M
Whole Genome Sequencing in Ethnically Diverse Cohorts for the ADSP Follow-Up Study (FUS)U01AG057659 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MAYEUX, RICHARD P, PERICAK-VANCE, MARGARET A. · 2017 to 2021
$34.4M
The Origins of Alzheimer Disease in African AmericansR01AG072547 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Rufus Olusola Akinyemi, GOLDIE S. BYRD · 2022 to 2026
$26.1M
Translational and Therapeutics CoreP30AG072959 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI JAGAN AYYAPPAN PILLAI · 2021 to 2026
$23.9M
Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American AncestriesU01AG084545 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDIE S. BYRD, ANTHONY JOHN GRISWOLD · 2024 to 2026
$14.9M
The Alzheimer Disease Sequence Analysis CollaborativeU01AG058654 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BUSH, WILLIAM S, FARRER, LINDSAY A. · 2018 to 2022
$14.6M
Functional genomic studies in diverse populations to characterize risk loci for Alzheimer DiseaseU01AG072579 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DYKXHOORN, DEREK MICHAEL, GRISWOLD, ANTHONY JOHN · 2021 to 2025
$6.9M
Replication and Extension of ADSP Discoveries in African-AmericansU01AG052410 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEECHAM, GARY WAYNE, BYRD, GOLDIE S. · 2016 to 2020
$5.2M
Identifying Protective Genetic Variants for APOE4RF1AG059018 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VANCE, JEFFERY MARVIN · 2018 to 2018
$4.4M
NIA NIH HHS P30 AG072959NIA NIH HHS R01 AG072547NIA NIH HHS RF1 AG059018NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG057659NIA NIH HHS U01 AG058654NIA NIH HHS U01 AG072579NIA NIH HHS U01 AG084545NIA NIH HHS U19 AG074865
6 · The paper itself

Abstract

Background: Neuropathological studies indicate a strong association between Alzheimer's disease (AD) and stroke, yet the molecular mechanisms underlying this association remain unclear. Methods: Local genetic correlation analysis was conducted with LAVA using the results from genome-wide association studies on AD and stroke in individuals of African ancestry. Enhanced Hi-C Capture Analysis (eHiCA) examined chromatin interactions using iPSC-derived cells from AD brain autopsy samples. Results: LAVA identified a region shared between AD and stroke on chromosome 18q21.33( Conclusions: This study identified a region on top of

Indexed as

Alzheimer’s diseasegenetic covariancestroke

Identifiers

PMID41404293
PMCPMC12704622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.