Evidence map›Paper›PMID 41404276›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Cannabis use and psychotic-like experiences in the

Emma C Johnson, Zhen Luo, Pamela N Romero Villela, Arpana Agrawal, Alexander S Hatoum, Nicole R Karcher

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0003-0394-777X
Zhen LuoDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Pamela N Romero VillelaDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-6401-3260
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-0313-793X
Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-8002-7267
Nicole R KarcherDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0001-5887-5529

Funding

Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics dataK01DA051759 · NIDA · WASHINGTON UNIVERSITY · PI JOHNSON, EMMA COVEY · 2021 to 2025
$816k
PRomoting Excellence through Pain and Addiction Research Enhancement (PREPARE)R90NR021799 · NINR · WASHINGTON UNIVERSITY · PI Burel R. Goodin · 2024 to 2026
$768k
NIDA NIH HHS K01 DA051759NINR NIH HHS R90 NR021799
6 · The paper itself

Abstract

Background and Hypothesis: Cannabis use has been linked to psychotic-like experiences (PLEs). Amid increasing legalization, we examined the extent to which cannabis use is associated with PLEs after adjusting for other risk factors in a contemporary United States sample. Study Design: We performed a cross-sectional analysis of self-reported cannabis use and four types of self-reported PLEs (auditory and visual perceptual distortions, referential ideation, and persecutory ideation) in the population-based biobank, the Study Results: Cannabis ever-use (ORs = 1.21 - 1.44, p-values < 2.7e-6) and more frequent past 3-month cannabis use (within lifetime ever-users) were associated with all four PLEs (χ Conclusions: Prior associations between cannabis use and PLEs may have been confounded by comorbid use of other substances. Future studies that distinguish cannabis use from other substance use in the etiology of PLEs could provide insight into this transdiagnostic construct.

Indexed as

gene-environment interactionsmethamphetaminepolygenic scorepsychosisschizophreniasubstance use

Identifiers

PMID41404276
PMCPMC12704650

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.