ArticleCureus2025
Diffusion Tensor Imaging Versus Conventional MRI in Temporal Lobe Epilepsy: A Comparative Study of Diagnostic Performance.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConventional magnetic resonance imaging (MRI) may appear normal in a proportion of patients with temporal lobe epilepsy (TLE). Diffusion tensor imaging (DTI) provides quantitative measures of white matter microstructure and may reveal subtle changes not visible on routine MRI. This study compared DTI-derived diffusion metrics with standard MRI epilepsy protocols in patients with unilateral TLE to assess the extent and pattern of white matter alterations.
methodsA cross-sectional observational study was conducted in the Department of Radiodiagnosis at Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India, with all MRI and DTI studies performed on a GE Signa Pioneer 3.0T system (GE Healthcare, DV26.0 software) using a dedicated 32-channel head coil. Twenty-one patients with confirmed TLE and 11 age-matched controls underwent both conventional MRI and DTI. Regions of interest (ROIs) were placed on the hippocampus, fornix, thalamus, corpus callosum, internal capsule, cingulum, and inferior fronto-occipital fasciculus (IFO) tracts. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were analyzed using IBM SPSS Statistics version 26.
resultsDTI revealed statistically significant alterations in FA and ADC values across multiple brain regions, including the hippocampus (FA: p < 0.05, ADC: p < 0.05), thalamus (FA: p << 0.001, ADC: p << 0.001), corpus callosum (FA: p << 0.001-0.05), internal capsule (FA: p << 0.001-0.05), and IFO tracts (FA and ADC: p << 0.001), demonstrating higher diagnostics compared to conventional MRI.
conclusionsThis study highlights that DTI offers additional microstructural information beyond conventional MRI in unilateral TLE. DTI may therefore serve as a complementary imaging tool, particularly in cases where standard MRI appears normal. Further diagnostic accuracy studies are required before DTI can be considered a superior or standalone modality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.