ReviewCureus2025
A Systematic Review and Meta-Analysis of Maternal Dengue Infection and Adverse Pregnancy Outcomes.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Trophoblast metabolic reprogramming triggers adverse pregnancy outcomes during DENV-2 infection in mice.Journal of virology · 2026Article
- Fetal-derived PF4+ tissue-resident macrophages recruit neutrophils as a key mechanism underlying DENV-2-induced intrauterine growth restriction in mice.PLoS pathogens · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV) infection is endemic in many regions with high fertility rates and poses a significant public health concern during pregnancy. This systematic review and meta-analysis aimed to evaluate the association between maternal dengue infection and adverse pregnancy outcomes. A comprehensive search of PubMed, Embase, and Web of Science was conducted up to July 11, 2025. Eligible studies were comparative observational in design, with laboratory-confirmed dengue infection in pregnant women and at least one fetal or neonatal outcome reported. Outcomes of interest included stillbirth rate (SBR), miscarriage rate (MBR), preterm birth rate (PBR), low birth weight (LBW), small for gestational age (SGA), neonatal death (ND), and postpartum hemorrhage (PPH). Random-effects models were employed to calculate pooled odds ratios (OR), and the risk of bias was assessed using the Newcastle-Ottawa Scale. A total of 35 studies encompassing approximately 65,000 pregnancies from 14 countries were included. Dengue infection during pregnancy was significantly associated with increased odds of stillbirth (OR 2.70; 95% CI: 1.44-5.10), miscarriage (OR 3.51; 95% CI: 1.15-10.77), and ND (OR 3.03; 95% CI: 1.17-7.83). Associations with preterm birth, LBW, and SGA were inconsistent but appeared stronger in cases of severe or first-trimester infections. These findings underscore the need for targeted clinical and public health interventions in dengue-endemic regions to mitigate maternal and perinatal risks. This review is registered with PROSPERO (CRD420251102253).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.