ArticleCureus2025
Renal Medullary Carcinoma: A Call for Screening and Early Diagnosis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal medullary carcinoma (RMC) is a highly aggressive malignancy associated strongly with sickle cell trait (SCT). This primarily affects young individuals, often presenting with nonspecific symptoms that cause delayed diagnosis, such as hematuria, flank pain, and weight loss, leading to a poor prognosis. We describe the case of a young adult man with no significant past medical history who presented to the emergency department with sudden-onset abdominal pain. Initial workup revealed mild anemia and microscopic hematuria. Contrast-enhanced computed tomography identified a right renal mass and retroperitoneal lymphadenopathy suggestive of metastatic disease. Renal biopsy confirmed RMC. Due to the advanced stage of disease and limited treatment options, the patient and his family opted for palliative care. He passed away at home several weeks later under hospice services. This case highlights the importance of considering RMC in young patients with SCT who present with unexplained abdominal pain and hematuria. Early recognition, multidisciplinary evaluation, and emphasis on supportive care are critical components in the management of this rare and aggressive malignancy.
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