ArticleCureus2025
Secondary Hypertrophic Osteoarthropathy (HOA) or Pierre Marie-Bamberger Syndrome Revealing Lung Adenocarcinoma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Digital clubbing, excruciating polyarthritis, and periosteal thickening of long bones are all features of the uncommon clinical syndrome known as hypertrophic osteoarthropathy (HOA). The most frequent association is lung cancer, which often presents as a paraneoplastic syndrome. We report the case of a 54-year-old male smoker who presented with joint pain and digital clubbing. Further investigations revealed a stage IV primary lung adenocarcinoma. Bone scintigraphy, performed after the diagnosis of the primary tumor, demonstrated increased uptake in the cortical bone of the lower limbs, with higher activity in both the axial and peripheral skeleton. The diagnosis of secondary HOA was established. The patient received palliative chemotherapy, which resulted in partial improvement of the articular symptoms. This case highlights the importance of considering HOA as a possible paraneoplastic manifestation, particularly in patients with lung cancer.
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