ArticleJournal of extracellular biology2025
Immune-Related Protein and Non-Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection.
Article in Journal of extracellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Immune-Related Protein and Non-Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection.Journal of extracellular biology · 2025Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs) promote intercellular communication, playing a key role in the secondary immune-related pathologies driven by chronic inflammation in people living with HIV (PLWH). To identify molecular components within large EVs (lEVs) from PLWH's plasma that may influence immune function and contribute to the pathological process. PLWH were classified using clinical data, cellular immunophenotyping, and plasma mediator profiling. lEVs were characterized using transcriptomic, proteomic, and interactome analysis. Their functional impact on immune cells was also assessed. PLWH showed signs of chronic basal inflammation. Compared to the control group, lEVs from PLWH carried the miR-4433b-3p, 31 long non-coding RNAs and 45 proteins differentially expressed. Key proteins-FBXO7, C3, SUGT1 and DTX3L-were linked to the miR-4433b-3p regulatory network, suggesting their involvement in inflammation. Interactome and pathway enrichment analysis associated these molecules to critical pathways, including NF-kappa B signalling and PI3K-AKT signalling. Finally, lEVs from PLWH more effectively modulated the production of inflammatory mediators in bystander immune cells. This study underscores the role of lEVs in shaping immune response during chronic HIV infection. By identifying specific molecular components, it provides valuable insights into potential therapeutic targets and candidate biomarkers for disease progression monitoring.
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