ArticleComputational and structural biotechnology journal2025
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The structural context of mutations in proteins predicts their effect on antibiotic resistance.eLife · 2026Article
- Beyond Random Splits: Assessing the Generalization of Graph and Vector Models for WT-Structure-Only Drug Resistance Prediction under Protein-Disjoint Evaluation.Computational and structural biotechnology journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tuberculosis mutation catalogue published by World Health Organization (WHO) lists a large number of mutations based on the statistical significance of their association with resistance or susceptibility to various drugs. However, the mechanism by which they confer resistance to drugs is often not understood. To address these gaps, we combined known resistance associated mutations from the WHO catalogue and newly discovered mutations by explainable artificial intelligence (XAI). In order to decipher the mechanistic basis of drug resistance, we examined where these mutations occur in three dimensional (3D) structures of key drug targets, measured their proximity to drug binding sites and compared their abundance in drug resistant as well as drug susceptible
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.