ArticleAnnals of Ibadan postgraduate medicine2025
ATRIAL FIBRILLATION: A REVIEW OF CONTEMPORARY EPIDEMIOLOGY AND ROLE OF INFLAMMATION IN THE PATHOPHYSIOLOGY.
Article in Annals of Ibadan postgraduate medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Atrial Fibrillation Modifies the Relationship Between Beta Blocker Dose and Physical Capacity After Myocardial Infarction.Clinics and practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Atrial Fibrillation (AF) is the most common form of sustained arrhythmia observed in clinical practice, and the incidence is rising in both developing and developed countries. It has been noted to contribute a major quota to the disability and death associated with cardiovascular diseases worldwide. Studies have shown that the pathophysiology of AF broadly revolves around electrical remodeling of the cardiac musculature, structural remodeling, calcium ion handling abnormalities, and autonomic nerve activation/remodeling. However, newer entities like inflammatory markers are emerging. Objective: The paper aims to review the current epidemiology of AF and the role of inflammatory markers in the pathogenesis of the condition. Methodology: This is a narrative review of the literature. We reviewed the contemporary epidemiology, pathophysiology, with a focus on the role of inflammatory markers such as interleukin-2, interleukin-6, C-reactive protein, and tumor necrosis factor. Results: Atrial fibrillation affects about 52.55 million individuals worldwide; prevalence and incidence increased by 137% and 124% between 1990 and 2021. The role of inflammation in the pathogenesis of AF and atrial flutter is increasingly being recognised. Elevated CRP predicts an increased risk of developing AF. TNF is associated with the pathogenesis of chronic AF, and levels in the plasma and left atrial tissue have a positive correlation with left atrial diameter. On the other hand, low IL-2 levels are associated with reduced incidence of postoperative AF. Interleukin 6 is associated with the generation and perpetuation of AF, and high levels correlate with the presence and duration of AF, as well as associated with the occurrence of AF post coronary artery bypass graft. Conclusion: Inflammatory markers are associated with increased incidence and prevalence of AF. Targeting this may offer novel insights into the prevention and treatment, thereby potentially reducing complications and improving patient outcomes in diverse settings.
Indexed as
Identifiers
41404087PMC12704339What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.