Evidence map›Paper›PMID 41404067›Full record

ArticleFrontiers in oncology2025

The value of

Huiwen Luo, Linlin Li, Jian Wang, Xuefeng Hou, Xiaofeng Li, Wengui Xu, Wen Zhou, Dong Dai

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huiwen LuoHealth Management Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Linlin LiTianjin's Clinical Research Center for Cancer, Tianjin, China.
Jian WangTianjin's Clinical Research Center for Cancer, Tianjin, China.
Xuefeng HouTianjin's Clinical Research Center for Cancer, Tianjin, China.
Xiaofeng LiTianjin's Clinical Research Center for Cancer, Tianjin, China.
Wengui XuTianjin's Clinical Research Center for Cancer, Tianjin, China.
Wen ZhouTianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, China.
Dong DaiTianjin's Clinical Research Center for Cancer, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We aimed to investigate the relationship between metabolic parameters based on Methods: In this single-center retrospective study, 115 patients with advanced NSCLC who underwent PD-1/PD-L1 ICI with/without chemotherapy with baseline Results: A total of 115 patients were enrolled in the group. After univariate and multivariate analyses, MTVwb [P = 0.002, HR 3.906 (3.644 - 9.279)] and treatment modality [P < 0.001, HR 8.11 (2.51 - 26.21)] were identified as independent prognostic factors for DCB. MTVwb [P = 0.012, HR 2.041 (1.173-3.552)] and treatment modality [P = 0.030, HR 2.045 (1.073 - 3.896)] are independent prognostic factors for PFS, while MTVwb [P =0.013, HR 4.173 (1.356-12.842)] is an independent influencing factor for OS. In the immunotherapy combination group, there was a significant correlation between PD-L1 expression and TLGwb (p Conclusions: Among patients with advanced NSCLC who received PD-1/PD-L1 ICIs in combination or without chemotherapy, MTVwb was an independent influencing factor for DCB, PFS, and OS. The treatment modality is also an independent influencing factor for DCB and PFS.

Indexed as

18F-FDGimmune checkpoint inhibitorNSCLCPET/CTprognosis

Identifiers

PMID41404067
PMCPMC12702758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.