Evidence map›Paper›PMID 41404029›Full record

ArticleToxicology reports2025

Modulating morphine-induced conditioned place preference: The role of diclofenac sodium.

Haneen Amawi, Rawan Alhazaimeh, Alaa M Hammad, Aseel O Rataan, Sahar Alsheyab, Tayma Maklouf, Bahaa Al-Trad, Karem H Alzoubi

Abstract read
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In one paragraph

Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haneen AmawiDepartment of Clinical Pharmacy and Pharmacy Practice, College of Pharmacy, Yarmouk University, Irbid 21163, Jordan.
Rawan AlhazaimehDepartment of Biological Sciences, Faculty of Science, Yarmouk University, Irbid 21163, Jordan.
Alaa M HammadDepartment of Pharmacy, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Aseel O RataanDepartment of Clinical Pharmacy and Pharmacy Practice, College of Pharmacy, Yarmouk University, Irbid 21163, Jordan.
Sahar AlsheyabDepartment of Biological Sciences, Faculty of Science, Yarmouk University, Irbid 21163, Jordan.
Tayma MakloufDepartment of Biological Sciences, Faculty of Science, Yarmouk University, Irbid 21163, Jordan.
Bahaa Al-TradDepartment of Biological Sciences, Faculty of Science, Yarmouk University, Irbid 21163, Jordan.
Karem H AlzoubiDepartment of Pharmaceutical Sciences, College of Pharmacy, QU-Health, Qatar University, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphine is known to induce strong reward-related behaviors, contributing to its high addiction potential. Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, have been suggested to modulate neuroinflammatory pathways involved in addiction. This study aimed to evaluate the effect of diclofenac sodium on morphine-induced conditioned place preference (CPP) in rats and investigate its underlying anti-inflammatory and antioxidant mechanisms. Female rats were subjected to a morphine-induced conditioned place preference (CPP) protocol. Diclofenac sodium (25 mg/kg) was administered 30 min prior to morphine conditioning sessions via injection. Post-conditioning, brain tissue samples were analyzed to measure the mRNA expression levels of cyclooxygenase enzymes (

Indexed as

Cox 1Cox 2CPP modelDiclofenac sodiumMorphineNSAID

Identifiers

PMID41404029
PMCPMC12704258

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.