ArticleClinical case reports2025
Beyond Infection and Lupus Flare: MPO-ANCA Microscopic Polyangiitis Causing Diffuse Alveolar Hemorrhage in a Patient With Systemic Lupus Erythematosus.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe an elderly woman with systemic lupus erythematosus (SLE) who presented with dyspnoea, anemia, and bilateral pulmonary infiltrates initially diagnosed as community-acquired pneumonia. Despite appropriate antibiotics, she failed to improve, and all microbiological investigations remained negative. Further immunological evaluation revealed perinuclear antineutrophil cytoplasmic antibody (p-ANCA) with anti-myeloperoxidase (MPO) specificity, establishing a diagnosis of microscopic polyangiitis (MPA) complicated by diffuse alveolar hemorrhage (DAH). This case illustrates a complex diagnostic dilemma in which pulmonary hemorrhage in a patient with SLE may represent either lupus-related pulmonary vasculitis or a new ANCA-associated process. It highlights the importance of reconsidering the diagnosis in non-resolving respiratory disease, particularly in patients with overlapping autoimmune conditions.
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