Evidence map›Paper›PMID 41403965›Full record

ArticleRadiology case reports2026

Gradual spontaneous regression of hepatic hemangioma in a woman with surgical menopause: A decade of imaging follow-up.

Sek Fong Leong, Ion Hou Ng, Man Teng Lio, Soi Chau Kong

Abstract readCase Reports
In one paragraph

Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sek Fong LeongDepartment of Radiology, Conde de São Januário General Hospital (CHCSJ), Macau.
Ion Hou NgDepartment of Radiology, Conde de São Januário General Hospital (CHCSJ), Macau.
Man Teng LioDepartment of Radiology, Conde de São Januário General Hospital (CHCSJ), Macau.
Soi Chau KongDepartment of Radiology, Conde de São Januário General Hospital (CHCSJ), Macau.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic hemangiomas (HHs), the most common benign liver tumors, may grow, remain stable, or rarely regress spontaneously, with regression potentially associated with reduced estrogen levels. We report a 67-year-old woman with a large HH exhibiting gradual regression (∼3 mm/year) over a decade of imaging post-surgical menopause in 2010, without hormone replacement therapy. Serial computed tomography (CT) and ultrasound (US) from 2014 to 2025 showed an initial 5.4 cm lesion, hypoechoic on US due to early-stage (F0-F1) metabolic dysfunction-associated steatotic liver disease (MASLD; Fibrosis-4 index <1.3) but with classic CT features (discontinuous peripheral nodular enhancement, centripetal fill-in). By 2025, the lesion regressed in size to ∼2 cm, and loss of previously seen regions of enhancement suggesting sclerosing. This case highlights gradual HH regression years after menopause, emphasizes multimodal imaging for MASLD-related US atypia, and supports conservative management for asymptomatic cases.

Indexed as

Estrogen withdrawalHepatic hemangiomaMetabolic dysfunction-associated steatotic liver diseaseSclerosing hemangiomaSpontaneous regression

Identifiers

PMID41403965
PMCPMC12704052

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.