Evidence map›Paper›PMID 41403942›Full record

ArticleFrontiers in immunology2025

Immune dysregulation in preeclampsia: integrative analysis of peripheral transcriptomes and placental single-cell land-scapes.

Shu Zheng, Peng Xu, Huimin Shen, Chang Shu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shu ZhengDepartment of Obstetrics, Obstetrics and Gynaecology Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Peng XuDepartment of Obstetrics, Obstetrics and Gynaecology Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Huimin ShenDepartment of Obstetrics, Obstetrics and Gynaecology Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Chang ShuDepartment of Obstetrics, Obstetrics and Gynaecology Center, The First Hospital of Jilin University, Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia (PE) is a pregnancy-specific disorder marked by systemic immune imbalance and placental dysfunction, yet the link between peripheral molecular changes and tissue-level immune alterations remains incompletely understood. In this study, we integrated bulk transcriptomic analysis of peripheral blood from pregnant women at high risk for PE with single-cell RNA sequencing (scRNA-seq) of placental tissues to identify key immune-associated genes and explore their functional relevance. Transcriptome-wide differential expression, immune cell deconvolution, co-expression network analysis, and machine learning-based feature selection led to the identification of five candidate genes. Among them,

Indexed as

PlacentaPre-EclampsiaTranscriptomeAdultBiomarkersFemaleGalectinsGene Expression ProfilingGene Regulatory NetworksHumansLectins, C-TypePregnancyProto-Oncogene ProteinsSingle-Cell AnalysisBiomarkersGalectinsLectins, C-TypeLGALS9 protein, humanProto-Oncogene Proteinsbiomarkersimmune dysregulationperipheral bloodplacentapreeclampsiasingle-cell RNA sequencingtranscriptome profiling

Identifiers

PMID41403942
PMCPMC12702750

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.