Evidence map›Paper›PMID 41403917›Full record

ArticleMedComm2025

Dysbiosis and Links of the Middle Ear, Nasal, and Oral Microbiota in Chronic Otitis Media with Effusion.

Jin Li, Shenglong Xu, Qin Gu, Xuan Sun, Yahan Zhao, Peng Zhang, Yi Li, Yan Zhao, Luo Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin LiDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.
Shenglong XuDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.
Qin GuDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.
Xuan SunDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.
Yahan ZhaoDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.ORCID https://orcid.org/0000-0002-9137-0247
Peng ZhangBeijing Key Laboratory For Genetics of Birth Defects Beijing Pediatric Research Institute MOE Key Laboratory of Major Diseases in Children Rare Disease Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.ORCID https://orcid.org/0000-0002-6218-1885
Yi LiDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.
Yan ZhaoDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.
Luo ZhangDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic otitis media with effusion (COME) is a common condition that can lead to hearing loss without acute inflammation. However, its underlying pathogenesis remains poorly understood, particularly with regard to microbial contributions. In this study, we characterized and compared the microbiota of the middle ear, nasal cavity, and oral cavity in 100 patients with COME and 77 controls using 16S rRNA gene sequencing. Alpha diversity, assessed by the Pielou index, was significantly reduced in the middle ear microbiota of COME patients compared with controls, and microbial compositions differed markedly across all sampled sites. Notably,

Indexed as

16S rRNA sequencingchronic otitis media with effusionmicrobial dysbiosismiddle ear microbiotanasal microbiotaoral microbiota

Identifiers

PMID41403917
PMCPMC12703046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.