Evidence map›Paper›PMID 41403889›Full record

ArticleBurns & trauma2025

Human urine-derived stem cells rescue cutaneous manifestation and suppress inflammation and fibrosis

Xingli Zhou, Jie Tan, Yuting Song, Pengcheng Liu, Xiwen Zhang, Xun Feng, Yue Xiao, Yiyi Wang, Guoqing Liu, Wenqian Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xingli ZhouDepartment of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.ORCID https://orcid.org/0000-0001-7060-254X
Jie TanDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yuting SongDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Pengcheng LiuDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Xiwen ZhangDepartment of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Xun FengDepartment of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yue XiaoDepartment of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yiyi WangDepartment of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Guoqing LiuDepartment of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Wenqian ZhangDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Qingyi ZhangDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yanlin JiangDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yuan LiuDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Longmei ZhaoDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Huiqi XieDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.ORCID https://orcid.org/0000-0003-0760-0853
Wei LiDepartment of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.ORCID https://orcid.org/0000-0002-9585-2884

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a life-threatening disease characterized by persistent wound inflammation, tissue fibrosis, and even tumorigenesis in later stages. Despite its significant impact on patient health worldwide, treatment of RDEB has limited options. There is a clear need for now interventions. The goal of this study was to explore the potential efficacy of urine-derived stem cells (USCs) in RDEB. Methods: We isolated human USCs from healthy donors, and assessed their therapeutic effects on RDEB both Results: USCs showed suppressive effects on expression of inflammation- and fibrosis-related genes involved in RDEB Conclusions: In summary, these results suggest the potential effects of USCs on improving the expression of C7 and would repair of RDEB, which supports the future use of USCs for the treatment of RDEB patients.

Indexed as

COL7A1Collagen VIIRecessive dystrophic epidermolysis bullosaTissue-engineered skinUrine-derived stem cell

Identifiers

PMID41403889
PMCPMC12704442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.