Evidence map›Paper›PMID 41403869›Full record

ArticleBioactive materials2026

miR-423-5p-enriched small extracellular vesicles drive periodontal regeneration via Sfrp2+ cell expansion.

Liya Ma, Yelin Zhang, Zijun Song, Pinwen Wang, Lu Liang, Mingzhu Chen, Xianmin Liao, Songtao Yang, Jiangtian Hu, Kai Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Advanced small extracellular vesicles delivery systems forExtracellular vesicles and circulating nucleic acids · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liya MaYunnan Key Laboratory of Stomatology & Department of Dental Research, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Yelin ZhangYunnan Key Laboratory of Stomatology & Department of Dental Research, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Zijun SongYunnan Key Laboratory of Stomatology & Department of Dental Research, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Pinwen WangYunnan Key Laboratory of Stomatology & Department of Dental Research, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Lu LiangYunnan Key Laboratory of Stomatology & Department of Dental Research, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Mingzhu ChenYunnan Key Laboratory of Stomatology & Department of Orthodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Xianmin LiaoStomatology Center, The First People's Hospital of Yunnan, Kunming, 650032, China.
Songtao YangYunnan Key Laboratory of Stomatology & Department of Endodontology, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Jiangtian HuYunnan Key Laboratory of Stomatology & Department of Orthodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.
Kai ChenSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China.
Hefeng YangYunnan Key Laboratory of Stomatology & Department of Dental Research, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small extracellular vesicles (sEVs) show therapeutic potential for periodontitis but functional components remain unclear, limiting clinical periodontal therapy application. Identifying key bioactive molecules and enhancing their functions via engineering strategies may overcome these limitations. By comparing the periodontal tropism of sEVs from different stem cells and conducting functional miRNA profiling, we identified miR-423-5p as a key component for periodontal ligament cell (PDLC) osteogenic differentiation by targeting

Indexed as

Dental follicle stem cellsEngineered extracellular vesiclesPeriodontal ligament stem cellsPeriodontal regenerationSmall extracellular vesicles

Identifiers

PMID41403869
PMCPMC12703869

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.