ArticleOchsner journal2025
The Potential Role of Zilretta in Reducing Intra-Articular Effusions.
Article in Ochsner journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoarthritis pain results from articular cartilage degeneration that leads to the breakdown and ulceration of the joint surface accompanied by hypertrophic bone changes with osteophyte formation. Steroids are commonly used to treat osteoarthritis pain. Case Report: An 81-year-old female with a medical history of bilateral knee osteoarthritis presented to the outpatient physical medicine and rehabilitation clinic for management of chronic bilateral knee pain and effusion. The patient had historically been managed with short-acting steroids, viscosupplementation, and deep genicular radiofrequency ablation. After changing providers, the patient underwent a series of image-guided intra-articular injections with the steroids Kenalog (triamcinolone) and Zilretta (triamcinolone acetonide extended-release injectable suspension) and was also treated with Monovisc (hyaluronic acid viscosupplementation). In addition, the patient underwent cryoneurolysis treatment (iovera° [Pacira BioSciences, Inc]). Injections were administered bilaterally when indicated, while cryoneurolysis was limited to the left knee. A substantial reduction in aspirated effusion volume was observed following Zilretta injections, with 92.6% and 88.1% reductions in aspirate volume in the patient's left and right knees, respectively. Conclusion: Steroids have anti-inflammatory properties that reduce pain and improve function in patients with osteoarthritis, but steroid use for chronic effusion management also needs to be considered. Given our patient's knee effusion reduction after Zilretta injection, research is needed to confirm the ability of Zilretta to effectively reduce chronic effusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.