Evidence map›Paper›PMID 41403832›Full record

ArticleiScience2025

Probiotic DNA epigenetically modulates KDM4A degradation to mitigate airway allergy.

Huanping Zhang, Xiaoyao Li, Mingxian Zhang, Xiaoxue Chen, Lihua Mo, Le Liu, Hanqing Zhang, Gaohui Wu, Qinmiao Huang, Yu Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huanping ZhangDepartment of Allergy Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.
Xiaoyao LiDepartment of Pulmonary and Critical Care Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.
Mingxian ZhangDepartment of Pulmonary and Critical Care Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.
Xiaoxue ChenDepartment of Allergy Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.
Lihua MoState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.
Le LiuState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.
Hanqing ZhangState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.
Gaohui WuDepartment of Respirology and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen 518055, China.
Qinmiao HuangDepartment of Respirology and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen 518055, China.
Yu LiuDepartment of Respirology and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen 518055, China.
Pingchang YangState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction of Type 1 regulatory T cells (Tr1 cells) is a key in airway allergy (AA), but mechanisms are unclear. This study explored if probiotic DNA restores Tr1 function in AA mice via USP14 and KDM4A. An AA mouse model (dust mite extracts) was used; techniques included flow cytometry (Tr1 function/Th2 polarization), ChIP, and ubiquitin immunoblotting (KDM4A, Il-10 promoter epigenetics). KDM4A-deficient CD4

Indexed as

health sciencesimmune responseimmunologymolecular biology

Identifiers

PMID41403832
PMCPMC12704312

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.