Evidence map›Paper›PMID 41403831›Full record

ArticleiScience2025

Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states.

Rohan H Savani, Le Wang, Yi Lu, Tiffany Le, Erin Park, Michael Yang, Zhiping P Pang, Mark A Rossi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rohan H SavaniCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Le WangCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Yi LuCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Tiffany LeCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Erin ParkCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Michael YangCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Zhiping P PangCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Mark A RossiCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.

Funding

Deciphering the neural basis of alcohol use disorders using human and mouse neuronsR01AA023797 · NIAAA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2016 to 2026
$4.8M
Synaptic and circuit mechanisms of central GLP-1 signaling in energy balanceR01DK131452 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2022 to 2026
$2.4M
Developing genetically-encoded detectors for neuropeptide release based on class B G-protein coupled peptide receptorsRF1MH120144 · NIMH · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI PANG, ZHIPING P. · 2019 to 2019
$2.2M
Lateral Hypothalamic circuit dysfunction underlying the development of diet-induced obesityR01DK136641 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Mark Allen Rossi · 2023 to 2026
$1.7M
A multiphoton system that allows simultaneous multiphoton imaging and 3D optical stimulationS10MH124725 · NIMH · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI PANG, ZHIPING P. · 2021 to 2021
$600k
NIAAA NIH HHS R01 AA023797NIDDK NIH HHS R01 DK131452NIDDK NIH HHS R01 DK136641NIMH NIH HHS RF1 MH120144NIMH NIH HHS S10 MH124725
6 · The paper itself

Abstract

Energy homeostasis is tightly regulated to ensure metabolic health in uncertain environments. Neurons expressing the glucagon-like peptide-1 receptor (GLP-1R) contribute to maintaining body weight, but how their activity is regulated according to energy state remains unclear. Here, we investigated the function and cellular dynamics of GLP-1R-expressing neurons of the paraventricular hypothalamus (PVH

Indexed as

behavioral neurosciencecellular neurosciencephysiology

Identifiers

PMID41403831
PMCPMC12704261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.