Evidence map›Paper›PMID 41403740›Full record

ArticleAdvanced pharmaceutical bulletin2025

The Use of Rare Earth Glass Microspheres and Graphene Quantum Dots Glass Microspheres for Biological Applications: Cancer Insight.

Jéssica Ingrid Faria De Souza, Natália Cristina Gomes-da-Silva, Filipe Ferreira Ascenção, Beatriz Da Silva Batista, Luciana Magalhães Rebelo Alencar, Pierre Basílio Almeida Fechine, Eduardo Ricci-Junior, Ralph Santos-Oliveira

Abstract read
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In one paragraph

Article in Advanced pharmaceutical bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jéssica Ingrid Faria De SouzaBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio De Janeiro, 21941906, RJ, Brazil.ORCID https://orcid.org/0000-0001-8827-9736
Natália Cristina Gomes-da-SilvaBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio De Janeiro, 21941906, RJ, Brazil.
Filipe Ferreira AscençãoBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio De Janeiro, 21941906, RJ, Brazil.
Beatriz Da Silva BatistaDepartment of Physics, Federal University of Maranhão, São Luis, 65065690, MA, Brazil.
Luciana Magalhães Rebelo AlencarDepartment of Physics, Federal University of Maranhão, São Luis, 65065690, MA, Brazil.
Pierre Basílio Almeida FechineGrupo De Química De Materiais Avançados (GQMat), Departamento De Química Analítica e Físico-Química, Universidade Federal Do Ceará-UFC, Campus Do Pici, CP 12100, Fortaleza, Ceará, CEP 60451-970, Brazil.
Eduardo Ricci-JuniorSchool of Pharmacy (Faculty), Federal University of Rio de Janeiro, Rio de Janeiro Brazil.
Ralph Santos-OliveiraBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio De Janeiro, 21941906, RJ, Brazil.ORCID https://orcid.org/0000-0002-0905-481X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study explores the use of glass microspheres doped with rare earth elements, specifically samarium (Sm) and neodymium (Nd), and graphene quantum dots (GQDs) in biological applications, particularly cancer therapy. Methods: Glass microspheres were synthesized using an eco-friendly approach with recycled glass and subsequently doped with Sm, Nd, or GQDs. The samples were characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). In vitro cytotoxicity was assessed in MCF-7 (breast cancer) and DU-145 (prostate cancer) cell lines. Results: In vitro assays demonstrated that these doped microspheres significantly reduced cell viability in breast (MCF-7) and prostate (DU-145) cancer cell lines. The GQD microspheres showed a marked reduction in cell proliferation, attributed to mechanisms involving apoptosis and reactive oxygen species (ROS) production. Sm and Nd microspheres also decreased cell survival, with Nd microspheres showing the highest efficacy. Conclusion: The study highlights the potential of rare earth elements and GQDs in developing advanced nanotherapeutic agents for cancer treatment, emphasizing their role in disrupting cellular functions and promoting cytotoxic effects in tumor cells.

Indexed as

Breast cancerOncologyProstate cancerTherapy

Identifiers

PMID41403740
PMCPMC12703382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.