Evidence map›Paper›PMID 41403738›Full record

ReviewAdvanced pharmaceutical bulletin2025

Platelet-Rich Plasma in Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis.

Sakineh Hajebrahimi, Fateme Tahmasbi, Elham Jahantabi, Gholamreza Hosseinpour, Rajesh Taneja, Hanieh Salehi-Pourmehr

Abstract readReview
In one paragraph

Review in Advanced pharmaceutical bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sakineh HajebrahimiResearch Center for Evidence-Based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-1494-7097
Fateme TahmasbiSocial Determinants of Health Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-0652-7693
Elham JahantabiDepartment of Urology, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-8209-2150
Gholamreza HosseinpourStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Rajesh TanejaUrology and Robotic Surgery Indraprastha Apollo Hospitals, New Delhi, India.
Hanieh Salehi-PourmehrResearch Center for Evidence-Based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0001-9030-2106

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This systematic review aims to critically evaluate the safety and efficacy of PRP therapy in managing interstitial cystitis/bladder pain syndrome (IC/BPS). Methods: Two researchers independently searched related Databases and collected all studies from inception to December 5, 2023. Outcome indicators of symptom relief were pain scores self-assessment using the VAS system, IC symptoms using the O'Leary-Sant score (OSS), urinary frequency, nocturia, post-void residual (PVR), voided volume, and functional bladder capacity. Results: Among 372 retrieved articles, 13 studies, including 426 patients, were included. The pain of patients decreased significantly after treatment with platelet-rich plasma (PRP) compared to the baseline values (MD: -1.93, 95% CI: -2.28, -1.58). All subgroup analyses revealed a decrease in VAS scores after PRP injection. IC symptoms using OSS, and ICSI decreased significantly after treatment. Conclusion: PRP therapy as a new and successful course of treatment may be a novel therapeutic approach in IC/BPS cases. More study with the control arm is required to enhance treatment regimens for this difficult condition and to better understand the mechanisms of action of PRP in IC/BPS.

Indexed as

IC/BPSInterstitial cystitis/bladder pain syndromePlatelet-rich plasmaPRPSystematic review

Identifiers

PMID41403738
PMCPMC12703394

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.