ArticleAdvanced pharmaceutical bulletin2025
Evaluating the Efficacy of a Semi-Solid Formulation with Clove Oil and Curcumin versus Clindamycin in the Treatment of Acne Vulgaris: A Comprehensive Study of Preclinical and Clinical Findings.
Article in Advanced pharmaceutical bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Purpose: Acne vulgaris is a chronic inflammatory condition affecting the pilosebaceous units. With the rise of antibiotic resistance and the potential side effects associated with conventional treatments, there is increasing interest in exploring natural alternatives for treating acne. This study aimed to formulate and clinically evaluate a topical gel containing clove oil and curcumin in patients with mild to moderate acne vulgaris, using topical clindamycin as a standard comparator. Methods: The antibacterial activity of clove oil and curcumin against Results: The clove oil-curcumin gel demonstrated comparable efficacy to clindamycin in reducing acne lesions, papules, and ASI. While no significant differences were observed between the two groups in comedone reduction, patient satisfaction increased in clove oil-curcumin gel group. Conclusion: Topical application of a gel containing clove oil and curcumin demonstrated promising results as an effective and well-tolerated alternative or adjunctive therapy for acne vulgaris. These findings support the potential of plant-based formulations in acne management.
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