ArticleClinical and translational radiation oncology2026
Cone beam computed tomography-guided online adaptive radiation therapy: Clinical implementation in breast and axillary target volumes.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Daily differences in breast contour and arm positioning can result in frequent re-positioning and offline re-planning in postoperative breast radiotherapy (RT). Online adaptive radiotherapy (oART) enables daily adaptation of the radiotherapy treatment plan. This study aimed to implement oART in breast and axillary target volumes to eliminate the need for repositioning and replanning. Materials and methods: Patients referred for postoperative partial breast irradiation (PBI) and whole breast irradiation (WBI)/post-mastectomy radiotherapy (PMRT) with or without axillary levels I-II (5x5.2 Gy) or I-IV (15x2.67 Gy) were included. On-couch treatment times were evaluated as well as dosimetry, target volume, acute toxicity, and in-house satisfaction questionnaires. Results: Seventy-nine patients (n = 66 PBI/WBI/PMRT, n = 13 WBI + axillary levels I-II/I-IV) were treated with postoperative RT (465 fractions). On-couch median time ranged from 14.5 (range: 10.1-29.2) minutes for right-sided WBI to 25.8 (range: 22.6-36.8) minutes for left-sided WBI + axillary levels I-II. All adapted treatment plans met the D98% ≥ 95 % coverage criteria for the target PTV. Relative breast CTV volumes for the adapted plan decreased in fraction 1 and increased in fractions 2-5 compared to the CTV volume on the planning CT. Toxicity was mainly grades 0 and 1 and patient satisfaction was good. Conclusion: Implementation of oART was feasible in all breast target volumes with acceptable treatment duration, only mild acute toxicity, favorable patient-reported comfort, and dosimetry that met clinical standards. Future work will focus on the implementation of oART in RT boost indications, and selection of breast cancer patients who will benefit most from oART.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.