ReviewFrontiers in cell and developmental biology2025
Probiotics and the intestinal tight junction barrier function.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of probiotics on immunological and clinical outcomes in allergic rhinitis: an umbrella review and updated meta-analysis of RCTs in children and adults.BMC immunology · 2026Pooled it
- From nutritional intervention to immune modulation: a multi-database bibliometric and topic modeling study of vitamin D in inflammatory bowel disease.Frontiers in immunology · 2026Pooled it
- Microbiome-Guided Maternal and Child Nutrition: A Structured Narrative Review of Indigenous African Foods, Fermented Foods, and Emerging Evidence.International journal of molecular sciences · 2026Review
- Stemness-associated MEF-derived extruded nanovesicles cooperate withNanoscale advances · 2026Article
- Safety and Effectiveness of Probiotic Preparations: A Contemporary Review.Diseases (Basel, Switzerland) · 2026Review
- A barrier-centered perspective on the gut-barrier-bone axis: a review of the core role of the intestinal barrier and related probiotics with nanocoatings.Archives of microbiology · 2026Review
- Sodium butyrate protects broiler chickens against lethal Salmonella Enteritidis infection by remodelling the gut microbiota and preserving immune homeostasis.Poultry science · 2026Article
- The Gut-Brain-Skin Axis: Systemic Effects of Functional Ingredients in Healthy Skin Aging.International journal of molecular sciences · 2026Review
- Host-derived Limosilactobacillus reuteri R30 and Cytobacillus solani Y5 improve growth performance and intestinal health of Danzhou chickens by regulating the jejunal microbiota.Poultry science · 2026Article
- Evaluation ofMicroorganisms · 2026Article
- Kidney Transplantation and the Gut-Kidney Axis: Microbial, Metabolic, and Nutritional Implications for Graft and Patient Outcomes.Nutrients · 2026Review
- Probiotic Bacteria in Stimulating Human Physiological Responses: Metabolic Function and Overall Health.Foods (Basel, Switzerland) · 2026Review
- Alginate Microcapsules Incorporating Recombinant Lactococcus lactis-Montmorillonite Complexes Enhance Bacterial Survival and Restore Intestinal Homeostasis in ETEC-Challenged Mice.Probiotics and antimicrobial proteins · 2026Article
- Characteristics of Placental Bacterial DNA Communities in Pregnant Women with Gestational Diabetes Mellitus and Association with Early Neonatal Gut Microbiota and Short-Term Perinatal Outcomes.Polish journal of microbiology · 2026Article
- Probiotics After Metabolic and Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Metabolites · 2026Review
- The role of the gut microbiota in radiation enteritis: from mechanistic insights to therapeutic applications.Communications biology · 2026Review
- Probiotics in colorectal cancer: mechanisms, biomarkers, and adjunct strategies.Cancer biology & medicine · 2026Review
- Fermented Dairy Products as Modulators of the Gut Microbiome: Greek Yogurt as a Model System.Food science & nutrition · 2026Review
- Prospects of Bioactive Compounds in Designing Functional Foods: Challenges and Solutions.Foods (Basel, Switzerland) · 2026Review
- Probiotic novel strain Lactobacillus reuteri MRD01 alleviates dextran sulfate sodium-induced colitis in male mice by promoting intestinal barrier integrity.Antonie van Leeuwenhoek · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disruption of the intestinal epithelial tight junction (TJ) barrier is a key pathogenic factor in numerous gastrointestinal (GI) disorders, including inflammatory bowel disease, irritable bowel syndrome, necrotizing enterocolitis, and enteric infections. The gut microbiota plays a pivotal role in regulating epithelial integrity, and emerging evidence highlights the therapeutic potential of probiotics in preserving or restoring TJ barrier function. This review summarizes the current literature on the protective effects of probiotics in modulating intestinal epithelial TJ barrier function. Specific strains of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.